Life Science
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From measurements in liquids to solid samples or soft tissues in life science varied samples are analyzed on a regular basis. With their convenient handling and versatile analytical capabilities the flexible WITec imaging systems provide the opportunity to adjust the imaging technique to changing requirements and are particularly well-suited for life science. The samples can be comprehensively characterized regarding their biochemical and physical properties and depth profiles and 3D images can be generated to visualize the results in a clear and accessible manner.
WITec’s highly versatile instruments can combine various imaging techniques to significantly increase the insights provided by measurement results. Possible combinations which can be included in a single microscope setup include confocal Raman imaging, Atomic Force Microscopy (AFM), Nearfield-Microscopy (SNOM) and Scanning Electron Microscopy (SEM). Confocal Raman imaging provides chemical information, AFM detects topography, structure, and physical properties such as stiffness, adhesion, etc. of the sample’s surface, and SNOM high-resolution measurements can optically reach beyond the diffraction limit. All WITec instrument configurations can be upgraded at any point to adapt the system to new or extended requirements.
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Confocal Raman image of an eukaryotic cell incubated with carbon-nano-tubes. Image on top: Scan in x-y- direction; Image on bottom: The depth-scan in z-direction reveals that the cell is penetrated by a nano-tube.
Application Examples
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Confocal Raman image of a hamster brain tissue. -
AFM image of a human chromosome. -
SNOM image of a nucleus.
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AFM image of a HeLa cell. -
Confocal Raman image of a wood cell. -
RISE Microscopy (Raman-SEM) image of a brain tissue.
Imaging Systems for Life Science
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alpha300 R for confocal Raman imaging
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alpha300 RA for combined Raman-AFM imaging
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RISE Microscopy for correlative Raman-SEM imaging
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